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Front Biosci. 2007 May 1;12:4011-9.

Roles of AKT signal in breast cancer.

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Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 627794-9626, USA.


The PI3K/Akt pathway plays a central role in a variety of cellular processes including cell growth, proliferation, motility and survival in both normal and tumor cells. The PI3K/Akt pathway is also instrumental in epithelial mesenchymal transitions and in angiogenesis during tumorigenesis. Many of the transforming events in breast cancer are a result of enhanced signaling of the PI3K/Akt pathway. Akt therefore is considered to be a rational target for cancer therapies and inhibitors of the PI3K/Akt pathway have been identified. In this review, we discuss the recent information about the functional roles of PI3K/Akt pathway in tumorigenesis and progression of breast cancer.

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