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Hua Xi Yi Ke Da Xue Xue Bao. 1991 Sep;22(3):337-9.

[Change of T lymphocyte subsets in peripherial blood of children with malnutrition and zinc deficiency].

[Article in Chinese]

Abstract

Sixty children with malnutrition were investigated in this study. The results showed a reduction of serum zinc in moderate and severe cases compared with the mild and normal groups. OKT3+, OKT4+ and OKT8+ cells in peripheral blood of mild malnutrition were significantly decreased in contrast to normal control. The reductive degree of OKT8+ and OKT4+ cells correlated with the severity of malnutrition. OKT8+, OKT4+ and OKT4+/OKT8+ ratio of moderate and severe malnutrition with infection were much lower than those without infection. Our findings suggested that main effective and regulative cells of cell-mediated immunity were impaired. OKT3+ and OKT4+ cells might be used as a sensitive index for early assessment of the immune function in malnutrition children.

PMID:
1748424
[Indexed for MEDLINE]

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