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Biophys J. 2007 Sep 1;93(5):1608-19. Epub 2007 May 4.

Curvature-dependent recognition of ethanolamine phospholipids by duramycin and cinnamycin.

Author information

1
Supra-Biomolecular System Research Group, RIKEN (Institute of Physical and Chemical Research) Frontier Research System, Saitama, Japan.

Abstract

Duramycin is a 19-amino-acid tetracyclic lantibiotic closely related to cinnamycin (Ro09-0198), which is known to bind phosphatidylethanolamine (PE). The lipid specificity of duramycin was not established. The present study indicates that both duramycin and cinnamycin exclusively bind to ethanolamine phospholipids (PE and ethanolamine plasmalogen). Model membrane study indicates that the binding of duramycin and cinnamycin to PE-containing liposomes is dependent on membrane curvature, i.e., the lantibiotics bind small vesicles more efficiently than large liposomes. The binding of the lantibiotics to multilamellar liposomes induces tubulation of membranes, as revealed by electron microscopy and small-angle x-ray scattering. These results suggest that both duramycin and cinnamycin promote their binding to the PE-containing membrane by deforming membrane curvature.

PMID:
17483159
PMCID:
PMC1948045
DOI:
10.1529/biophysj.106.101584
[Indexed for MEDLINE]
Free PMC Article

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