Format

Send to

Choose Destination
See comment in PubMed Commons below
Mitochondrion. 2007 Jun;7 Suppl:S41-50. Epub 2007 Mar 16.

The antioxidant role of coenzyme Q.

Author information

1
Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.

Abstract

A number of functions for coenzyme Q (CoQ) have been established during the years but its role as an effective antioxidant of the cellular membranes remains of dominating interest. This compound is our only endogenously synthesized lipid soluble antioxidant, present in all membranes and exceeding both in amount and efficiency that of other antioxidants. The protective effect is extended to lipids, proteins and DNA mainly because of its close localization to the oxidative events and the effective regeneration by continuous reduction at all locations. Its biosynthesis is influenced by nuclear receptors which may give the possibility, in the future, by using agonists or antagonists, of reestablishing the normal level in deficiencies caused by genetic mutations, aging or cardiomyopathy. An increase in CoQ concentration in specific cellular compartments in the presence of various types of oxidative stress appears to be of considerable interest.

PMID:
17482888
DOI:
10.1016/j.mito.2007.02.006
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center