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Mitochondrion. 2007 Jun;7 Suppl:S62-71. Epub 2007 Mar 30.

Endogenous synthesis of coenzyme Q in eukaryotes.

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1
Department of Chemistry and Biochemistry, Molecular Biology Institute, University of California, 607 Charles E. Young Drive East, Los Angeles, CA 90095-1569, USA.

Abstract

Coenzyme Q (Q) functions in the mitochondrial respiratory chain and serves as a lipophilic antioxidant. There is increasing interest in the use of Q as a nutritional supplement. Although, the physiological significance of Q is extensively investigated in eukaryotes, ranging from yeast to human, the eukaryotic Q biosynthesis pathway is best characterized in the budding yeast Saccharomyces cerevisiae. At least ten genes (COQ1-COQ10) have been shown to be required for Q biosynthesis and function in respiration. This review highlights recent knowledge about the endogenous synthesis of Q in eukaryotes, with emphasis on S. cerevisiae as a model system.

PMID:
17482885
PMCID:
PMC1974887
DOI:
10.1016/j.mito.2007.03.007
[Indexed for MEDLINE]
Free PMC Article
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