Format

Send to

Choose Destination
Cell. 2007 May 4;129(3):465-72.

Hypoxia-inducible factors, stem cells, and cancer.

Author information

1
Abramson Family Cancer Research Institute, University of Pennsylvania, 453 BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA. bkeith@mail.med.upenn.edu <bkeith@mail.med.upenn.edu>

Abstract

Regions of severe oxygen deprivation (hypoxia) arise in tumors due to rapid cell division and aberrant blood vessel formation. The hypoxia-inducible factors (HIFs) mediate transcriptional responses to localized hypoxia in normal tissues and in cancers and can promote tumor progression by altering cellular metabolism and stimulating angiogenesis. Recently, HIFs have been shown to activate specific signaling pathways such as Notch and the expression of transcription factors such as Oct4 that control stem cell self renewal and multipotency. As many cancers are thought to develop from a small number of transformed, self-renewing, and multipotent "cancer stem cells," these results suggest new roles for HIFs in tumor progression.

PMID:
17482542
PMCID:
PMC3150586
DOI:
10.1016/j.cell.2007.04.019
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center