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Micron. 2008 Jun;39(4):373-9. Epub 2007 Mar 24.

Bone repair in rat mandible by rhBMP-2 associated with two carriers.

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Faculdade de Odontologia, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brasil.


This study evaluated the quantity and quality of newly formed bone, stimulated by rhBMP-2 in combination with monoolein or chitosan gel as carriers, in critical bone defects created in 36 Wistar rat mandibles. Two weeks after surgery, the animals were anesthetized with 37.5% urethane submitted to perfusion and the hemi-mandibles removed for histological and histomorphometrical analysis. The results showed that there was a statistical difference between groups of animals receiving or not rhBMP-2 (p<0.05). Newly formed bone was more intense in the occlusal region, followed by the basal and middle regions, respectively. Both carriers, monoolein and chitosan gels were adequate for defect filling and control of protein release.

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