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Prostaglandins Other Lipid Mediat. 2007 May;83(3):162-74. Epub 2007 Jan 25.

5-lipoxygenase: regulation and possible involvement in atherosclerosis.

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1
Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institute, S-17177 Stockholm, Sweden. olof.radmark@ki.se

Abstract

This review article focuses on two aspects regarding 5-lipoxygenase. First, mechanisms for activation of the enzyme. Second, the involvement of 5-lipoxygenase and leukotrienes in atherosclerosis.

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