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Science. 2007 May 4;316(5825):758-61.

Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons.

Author information

1
Department of Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.

Abstract

We found that, in the mouse visual cortex, action potentials generated in a single layer-2/3 pyramidal (excitatory) neuron can reliably evoke large, constant-latency inhibitory postsynaptic currents in other nearby pyramidal cells. This effect is mediated by axo-axonic ionotropic glutamate receptor-mediated excitation of the nerve terminals of inhibitory interneurons, which connect to the target pyramidal cells. Therefore, individual cortical excitatory neurons can generate inhibition independently from the somatic firing of inhibitory interneurons.

PMID:
17478724
DOI:
10.1126/science.1135468
[Indexed for MEDLINE]
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