An estimated 50,000 women and children are annually trafficked into the United States, resulting in complex health and social consequences and significant risk for violence. This article presents a case of a trafficked woman identified in the U.S. health system and describes the vulnerabilities to forced prostitution as a result of trafficking and the challenges in providing an effective and comprehensive response to meet safety and health care needs. Health care providers are in a unique position to identify and support U.S. sex trafficking victims; thus, education and training for health care professionals on trafficking is needed.