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J Biomed Opt. 2007 Mar-Apr;12(2):020501.

Real-time microscopic visualization of tissue response to laser thermal therapy.

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Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, 55 Fruit Street, BAR 703, Boston, Massachusetts 02114, USA.


We present methods for visualizing the dynamic response of biological samples to laser-induced heating. Our approach utilizes optical frequency-domain imaging to detect, spatially localize, and monitor unique dynamic signatures that arise within zones of active tissue denaturation. Since this information is precisely registered with high-resolution ( approximately 10 microm) cross sectional images, regions of thermally destroyed tissue can be mapped in relation to pre-existing morphology. Using porcine esophageal specimens ex vivo, we demonstrate that the extent and evolution of laser thermal damage can be assessed in real time.

[Indexed for MEDLINE]

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