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J Proteome Res. 2007 Jun;6(6):2057-67. Epub 2007 May 4.

Tag-mass: specific molecular imaging of transcriptome and proteome by mass spectrometry based on photocleavable tag.

Author information

1
Laboratoire de Neuroimmunologie des Annélides, FRE CNRS 2933, MALDI Imaging Team, Université des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq Cedex, France.

Abstract

MALDI tissue imaging of tissues has become a promising technique for tracking biomarkers while determining their location and structural characterization. We have now developed specific targeting probes (oligonucleotides, antibodies), named Tag-Mass. This approach is based on probes modified with a photocleavable linker coupled with a tag cleaved and detected using mass spectrometry. Tag-Mass development is the key for a rapid, sensitive, and accurate approach to correlate levels of expression of different mRNA or proteins in diseases.

PMID:
17477556
PMCID:
PMC2947822
DOI:
10.1021/pr0700044
[Indexed for MEDLINE]
Free PMC Article

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