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J Clin Invest. 2007 May;117(5):1155-66.

Altered macrophage differentiation and immune dysfunction in tumor development.

Author information

1
Istituto Clinico Humanitas, Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, Italy.

Abstract

Tumors require a constant influx of myelomonocytic cells to support the angiogenesis and stroma remodeling needed for their growth. This is mediated by tumor-derived factors, which cause sustained myelopoiesis and the accumulation and functional differentiation of myelomonocytic cells, most of which are macrophages, at the tumor site. An important side effect of the accumulation and functional differentiation of these cells is that they can induce lymphocyte dysfunction. A complete understanding of the complex interplay between neoplastic and myelomonocytic cells might offer novel targets for therapeutic intervention aimed at depriving tumor cells of important growth support and enhancing the antitumor immune response.

PMID:
17476345
PMCID:
PMC1857267
DOI:
10.1172/JCI31422
[Indexed for MEDLINE]
Free PMC Article

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