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J Clin Invest. 2007 May;117(5):1137-46.

Immune surveillance of tumors.

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1
Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne 8006, Victoria, Australia.

Abstract

The ability of the immune system to identify and destroy nascent tumors, and to thereby function as a primary defense against cancer, has been debated for many decades. Recent findings by a number of investigators in both mouse models of cancer and humans with cancer now offer compelling evidence that particular immune cell types, effector molecules, and pathways can sometimes collectively function as extrinsic tumor suppressor mechanisms. This work provides the basis for further study of natural immunity to cancer and for rational use of this information in the design of immunotherapies in combination with other conventional cancer treatments.

PMID:
17476343
PMCID:
PMC1857231
DOI:
10.1172/JCI31405
[Indexed for MEDLINE]
Free PMC Article
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