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J Clin Invest. 2007 May;117(5):1130-6.

Harnessing the immune system to treat cancer.

Author information

1
Departments of Pathology, Medicine, and Dermatology, New York University School of Medicine, NYU Medical Center, 550 First Avenue, New York, NY 10016, USA. nina.bhardwaj@med.nyu.edu

Abstract

A major challenge for the immune system is to recognize and eliminate cells undergoing carcinogenesis. Immune defense against tumors is complex. It can be mediated early by the innate immune system (i.e., phagocytes, NK cells, NKT cells, cytokines, and complement proteins) and later by the adaptive immune system (i.e., B cells and T cells). The eight articles in this Review series on tumor immunology discuss the mechanisms underlying immune surveillance of tumors, the regulation of carcinogenesis by immune inflammatory mediators, current approaches to controlling tumor growth through immunotherapy, and novel targets of immunotherapy.

PMID:
17476342
PMCID:
PMC1857237
DOI:
10.1172/JCI32136
[Indexed for MEDLINE]
Free PMC Article

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