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BMJ. 1991 Nov 9;303(6811):1163-5.

Predictive value for coeliac disease of antibodies to gliadin, endomysium, and jejunum in patients attending for jejunal biopsy.

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  • 1Regional Immunology Laboratory, Belfast City Hospital.

Abstract

OBJECTIVE:

To investigate the extent to which the detection of antibodies to gliadin, endomysium, and jejunum predicts the eventual diagnosis of coeliac disease according to the revised ESPGAN diagnostic criteria in a group of patients in whom there is a high suspicion of coeliac disease.

DESIGN:

Clinical assessment and laboratory analysis of patients with suspected coeliac disease.

SETTING:

Gastroenterology department of teaching hospital.

PATIENTS:

96 adults with suspected coeliac disease attending for jejunal biopsy.

MAIN OUTCOME MEASURES:

Diagnosis of coeliac disease with the revised criteria of the European Society of Paediatric Gastroenterology and Nutrition in patients with and without antibodies associated with coeliac disease.

RESULTS:

28 patients had a clinical diagnosis of coeliac disease, seven of other gastrointestinal diseases, and 12 of miscellaneous diseases; 49 had no diagnosis. Gliadin IgA detected by ELISA was found in all patients with coeliac disease and none of those without, giving a sensitivity, specificity, positive and negative predictive values, and predictive efficiency of 100% for diagnosing coeliac disease within the group. Endomysial IgA was found in 25 (89%) patients with coeliac disease and jejunal IgA in 21 (75%); neither IgA was found in patients without coeliac disease.

CONCLUSION:

Detection of gliadin IgA by ELISA and to a lesser extent the endomysial IgA should allow better selection of patients for jejunal biopsy and thus make diagnosing coeliac disease simpler and more efficient.

PMID:
1747612
PMCID:
PMC1671497
[PubMed - indexed for MEDLINE]
Free PMC Article
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