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Nat Rev Mol Cell Biol. 2007 Jun;8(6):479-90.

RNA-binding proteins: modular design for efficient function.

Author information

1
Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.

Abstract

Many RNA-binding proteins have modular structures and are composed of multiple repeats of just a few basic domains that are arranged in various ways to satisfy their diverse functional requirements. Recent studies have investigated how different modules cooperate in regulating the RNA-binding specificity and the biological activity of these proteins. They have also investigated how multiple modules cooperate with enzymatic domains to regulate the catalytic activity of enzymes that act on RNA. These studies have shown how, for many RNA-binding proteins, multiple modules define the fundamental structural unit that is responsible for biological function.

PMID:
17473849
PMCID:
PMC5507177
DOI:
10.1038/nrm2178
[Indexed for MEDLINE]
Free PMC Article

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