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J Biol. 2007;6(2):3.

Multilevel regulation of growth rate in yeast revealed using systems biology.

Author information

1
The Broad Institute of Harvard & MIT, Chemical Biology Program, 7 Cambridge Center, Cambridge, MA 02142, USA.

Abstract

The effect of changing growth rates on the transcriptome, proteome and metabolome has been systematically studied. Measurements made under varying nutrient conditions, corresponding to biochemical pathways that correlate primarily with growth rate, reveal a central role for mitochondrial metabolism and the TOR (target of rapamycin) signaling pathway.

PMID:
17472733
PMCID:
PMC2373900
DOI:
10.1186/jbiol56
[Indexed for MEDLINE]
Free PMC Article

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