Petrous apex aspergillosis as a long-term complication of cholesterol granuloma

Laryngoscope. 2007 Jul;117(7):1199-201. doi: 10.1097/MLG.0b013e3180536721.

Abstract

Aspergillus infection of the petrous apex is a rare and devastating condition. To date, only two such cases have been reported, which resulted from direct extension of chronic Aspergillus otitis media. We present a case of petrous apex aspergillosis occurring years after surgical drainage of a petrous apex granuloma cyst. Because of the potential lethal nature of this condition, aggressive surgical therapy should be considered early in this illness and may provide the best chance for survival.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Antifungal Agents / therapeutic use
  • Aspergillus fumigatus / isolation & purification*
  • Basilar Artery / microbiology
  • Cerebrospinal Fluid Rhinorrhea / drug therapy
  • Cerebrospinal Fluid Rhinorrhea / etiology
  • Cholesterol*
  • Fatal Outcome
  • Fluconazole / therapeutic use
  • Granuloma, Foreign-Body / complications*
  • Granuloma, Foreign-Body / surgery
  • Headache / etiology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Methicillin Resistance
  • Middle Aged
  • Neuroaspergillosis / drug therapy
  • Neuroaspergillosis / etiology*
  • Neuroaspergillosis / pathology
  • Ofloxacin / therapeutic use
  • Otorhinolaryngologic Surgical Procedures
  • Petrous Bone / microbiology*
  • Petrous Bone / pathology
  • Sphenoid Sinus / surgery
  • Subarachnoid Space / microbiology

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Amphotericin B
  • Fluconazole
  • Cholesterol
  • Ofloxacin