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Proc Natl Acad Sci U S A. 2007 May 8;104(19):8155-60. Epub 2007 Apr 30.

Long-term effects of chronic nicotine exposure on brain nicotinic receptors.

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1
Récepteurs et Cognition, Centre National de la Recherche Scientifique Unité de Recherche Associée 2182, Unité de Neurobiologie Intégrative des Systémes Cholinergiques, Institut Pasteur, 75724 Paris, France.

Abstract

Chronic nicotine exposure results in long-term homeostatic regulation of nicotinic acetylcholine receptors (nAChRs) that play a key role in the adaptative cellular processes leading to addiction. However, the relative contribution of the different nAChR subunits in this process is unclear. Using genetically modified mice and pharmacological manipulations, we provide behavioral, electrophysiological, and pharmacological evidence for a long-term mechanism by which chronic nicotine triggers opposing processes differentially mediated by beta2*- vs. alpha7*nAChRs. These data offer previously undescribed insights into the understanding of nicotine addiction and the treatment of several human pathologies by nicotine-like agents chronically acting on beta2*- or alpha7*nAChRs.

PMID:
17470777
PMCID:
PMC1859991
DOI:
10.1073/pnas.0702698104
[Indexed for MEDLINE]
Free PMC Article
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