Format

Send to

Choose Destination
Hypertens Pregnancy. 2007;26(2):173-8.

Maternal hemodynamic changes associated with furosemide treatment.

Author information

1
Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, USA. darcarr@u.washington.edu

Abstract

OBJECTIVE:

To assess the pharmacodynamic effects of furosemide in pregnancy.

METHODS:

Twenty-one pregnant women who received furosemide 20 mg daily had cardiac output (CO), stroke volume (SV), and total peripheral resistance (TPR) measured by Doppler technique before and after treatment.

RESULTS:

Furosemide was initiated at 22.4 +/- 6.0 weeks gestation. CO and SV decreased (mean +/- SD: 1.2 +/- 0.2 L/min and 17+/-3 mL, respectively), whereas TPR increased (101+/-26 dyne.sec.cm(-5); p < 0.001 for all) after 2.9+/-1.4 weeks. Hemodynamics did not approach the expected mean for pregnancy.

CONCLUSIONS:

While furosemide improved the hyperdynamic circulation in pregnancy, it did not lower blood pressure or cause clinically significant vasoconstriction.

PMID:
17469007
DOI:
10.1080/10641950701204489
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center