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Med Sci Sports Exerc. 2007 May;39(5):816-20.

Creatine monohydrate increases bone mineral density in young Sprague-Dawley rats.

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1
Departments of Pediatrics and Medicine, McMaster University, Hamilton, Canada.

Abstract

INTRODUCTION:

Creatine kinase, found in osteoblasts, is an enzyme that is upregulated in response to interventions that enhance bone mass accretion. Creatine monohydrate supplementation can increase fat-free mass in young healthy men and women and can reduce markers of bone breakdown in boys with Duchenne muscular dystrophy.

PURPOSE:

The objective of this study was to determine the influence of supplementation with creatine monohydrate on bone structure and function in growing rats, to establish a therapeutic model.

MATERIALS AND METHODS:

Creatine monohydrate (2% w.w.) (CR; N = 16) or standard rat chow (CON; N = 16) was fed to Sprague-Dawley rats beginning at 5 wk of age, for 8 wk. Bone mineral density (BMD) and content (BMC) were assessed using dual-energy x-ray absorptiometry at the beginning and end of the protocol. The rats were sacrificed, and one femur was removed for the determination of mechanical properties.

RESULTS:

The CR-treated rats showed greater lumbar BMD and femoral bending load at failure compared with the CON rats (P < 0.05).

CONCLUSIONS:

Together, these data suggest that creatine monohydrate potentially has a beneficial influence on bone function and structure; further investigation is warranted into its effect on bone functional properties and its effects in disorders associated with bone loss.

PMID:
17468579
DOI:
10.1249/mss.0b013e318031fac4
[Indexed for MEDLINE]

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