Format

Send to

Choose Destination
Dig Dis. 2007;25(2):129-37.

The anorexia of aging.

Author information

1
Department of Biomedical and Surgical Sciences, Geriatric Unit, University of Verona, Verona, Italy. vincenzo.difrancesco@univr.it

Abstract

Malnutrition in the elderly is one of the greatest threats to health, well-being and autonomy, it is therefore crucial to understand and to contrast the causal factors of inadequate energy intake. This review focuses on the mechanisms of the so-called 'anorexia of aging'. In recent years, it has been shown that elderly subjects have abnormal peripheral signal patterns and alterations in central hypothalamic control relays. Negative feedback from impaired gastric motility, exaggerated long-term adiposity signals (leptin, insulin) and postprandial anorexigenic signals (CCK, PYY) seem to prevail over the central feeding drive. If nutritional strategies of intervention are to be improved, these data need to be taken into account.

PMID:
17468548
DOI:
10.1159/000099477
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland
Loading ...
Support Center