Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2007 Jun 15;17(12):3258-61. Epub 2007 Apr 10.

Discovery of new C3aR ligands. Part 1: arginine derivatives.

Author information

1
UCB Global Chemistry, Chemin du Foriest R4, 1420 Braine l'Alleud, Belgium. frederic.denonne@ucb-group.com

Abstract

The synthesis and in vitro binding of several new arginine-containing C3aR ligands are reported. DMPK properties and functional activities of selected compounds have been evaluated. One compound is shown to be active in an in vivo model of airway inflammation after aerosol administration.

PMID:
17467987
DOI:
10.1016/j.bmcl.2007.04.022
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center