Format

Send to

Choose Destination
See comment in PubMed Commons below
J Am Acad Dermatol. 2007 Aug;57(2):361-4. Epub 2007 Apr 30.

Schnitzler syndrome: treatment failure to rituximab but response to anakinra.

Author information

1
Department of Dermatology, University of Kiel, Germany.

Abstract

Schnitzler syndrome is a rare disease characterized by a chronic urticarial rash and a monoclonal gammopathy. The exact pathogenesis is still uncertain and treatment remains a challenge. Here, we report a patient who was only recently given the diagnosis of Schnitzler syndrome although the typical symptoms had been present for about 6 years. Administration of the B-cell antibody rituximab did not exert any beneficial effect despite effective elimination of B cells and a reduction of the paraprotein. In contrast, injection of the interleukin-1-receptor antagonist anakinra caused a complete remission within a few days.

PMID:
17467852
DOI:
10.1016/j.jaad.2007.03.036
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center