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Behav Brain Res. 2007 Jul 19;181(1):12-22. Epub 2007 Mar 25.

Functional neural networks underlying response inhibition in adolescents and adults.

Author information

1
Olin Neuropsychiatry Research Center, Hartford, CT 06106, United States.msteven@harthosp.org

Abstract

This study provides the first description of neural network dynamics associated with response inhibition in healthy adolescents and adults. Functional and effective connectivity analyses of whole brain hemodynamic activity elicited during performance of a Go/No-Go task were used to identify functionally integrated neural networks and characterize their causal interactions. Three response inhibition circuits formed a hierarchical, inter-dependent system wherein thalamic modulation of input to premotor cortex by fronto-striatal regions led to response suppression. Adolescents differed from adults in the degree of network engagement, regional fronto-striatal-thalamic connectivity, and network dynamics. We identify and characterize several age-related differences in the function of neural circuits that are associated with behavioral performance changes across adolescent development.

PMID:
17467816
PMCID:
PMC2266817
DOI:
10.1016/j.bbr.2007.03.023
[Indexed for MEDLINE]
Free PMC Article

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