Objective: To disclose the relationship between a derivative chromosome 9 and recurrent pregnancy loss.
Design: Case report.
Setting: Referral from primary clinical care to tertiary hospital for further intervention.
Patient(s): A 31-year-old woman who had four recurrent early spontaneous abortions.
Intervention(s): Cytogenetic and fluorescence in situ hybridization analyses of the chromosome harvested from peripheral blood sample.
Main outcome measure(s): Karyotype of the patient.
Result(s): The patient has a unique derivative chromosome 9, der(9)(9qter-->9p24::9p24-->9p11::9p13-->9qter). ish der(9) (CEP9x1,43N6x1,D9Z3x1).
Conclusion(s): Maternal derivative chromosome 9 may cause recurrent pregnancy loss.