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Toxicol Appl Pharmacol. 2007 Jun 1;221(2):131-47. Epub 2007 Mar 12.

Manganese: recent advances in understanding its transport and neurotoxicity.

Author information

  • 1Department of Pediatrics, and The Kennedy Center for Research on Human Development, Vanderbilt University, School of Medicine, Nashville, TN 37232-2495, USA. michael.aschner@vanderbilt.edu

Abstract

The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport of manganese (Mn) into the central nervous system (CNS), as well as brain imaging and neurocognitive studies in non-human primates aimed at improving our understanding of the mechanisms of Mn neurotoxicity. Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans.

PMID:
17466353
PMCID:
PMC1950780
DOI:
10.1016/j.taap.2007.03.001
[PubMed - indexed for MEDLINE]
Free PMC Article
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