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PLoS Comput Biol. 2007 Apr 27;3(4):e43.

Deciphering protein-protein interactions. Part II. Computational methods to predict protein and domain interaction partners.

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1
Computational Biology Branch, National Center for Biotechnology Information, Bethesda, Maryland, United States of America.

Abstract

Recent advances in high-throughput experimental methods for the identification of protein interactions have resulted in a large amount of diverse data that are somewhat incomplete and contradictory. As valuable as they are, such experimental approaches studying protein interactomes have certain limitations that can be complemented by the computational methods for predicting protein interactions. In this review we describe different approaches to predict protein interaction partners as well as highlight recent achievements in the prediction of specific domains mediating protein-protein interactions. We discuss the applicability of computational methods to different types of prediction problems and point out limitations common to all of them.

PMID:
17465672
PMCID:
PMC1857810
DOI:
10.1371/journal.pcbi.0030043
[Indexed for MEDLINE]
Free PMC Article
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