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Eye (Lond). 2007 Dec;21(12):1524-7. Epub 2007 Apr 20.

Intraocular use of rituximab.

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1
Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA.

Abstract

PURPOSE:

To evaluate the toxicity of 1 mg of intraocular rituximab and to present a small case-series of patients treated with intravitreal rituximab.

METHODS:

Rituximab (1 mg/0.1 ml) was injected in the vitreous of one eye of three Dutch-belted rabbits. Two animals were injected with balanced salt solution as controls. At 1 month the rabbits were killed and the eyes examined by light microscopy. Three patients (five eyes) with intraocular lymphoma were also treated with a 1 mg injection of rituximab.

RESULTS:

The treated rabbit eyes and the control eyes showed no light microscopic evidence of ocular toxicity at 1 month following injection. The five human eyes of three patients have shown no evidence of intraocular toxicity with a median follow-up time of 3.6 months (range 2.0-6.4 months). One patient received a total of four injections in the right eye and three injections in the left eye.

CONCLUSION:

Intravitreal rituximab at a dose of 1 mg does not appear to cause toxicity in rabbit eyes and in the five eyes of three patients.

Comment in

PMID:
17464308
DOI:
10.1038/sj.eye.6702804
[Indexed for MEDLINE]
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