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Mol Cells. 2007 Feb 28;23(1):94-9.

PMA activates Stat3 in the Jak/Stat pathway and induces SOCS5 in rat brain astrocytes.

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1
Research Institute, National Cancer Center, Goyang 411-764, Korea.

Abstract

Suppressors of cytokine signaling (SOCS) family members are negative feedback regulators of the Jak/Stat pathway, which is an essential inflammatory signaling pathway. We investigated expression of eight members of the SOCS family in rat astrocytes, using two inflammatory stimulants, PMA and IFN-gamma. Only a few SOCS genes were induced by both stimulants, and we detected an increase in SOCS5 protein with PMA. PMA activated the Jnk, Erk, p38, and Jak/Stat signal pathways. In addition, it increased the level of activated-Stat3 resulting from tyrosine phosphorylation. A gel-shift assay showed that a protein in nuclear extracts from PMA-treated cells was able to bind to Stat binding elements. These results suggest that activated Stat3 binds to SOCS promoters and leads to their transcriptional induction.

PMID:
17464217
[Indexed for MEDLINE]
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