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Am J Public Health. 2007 Jun;97(6):1047-52. Epub 2007 Apr 26.

Reproductive health of adolescent girls perinatally infected with HIV.

Author information

1
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Mass 02115-6017, USA. sbrogly@sdac.harvard.edu

Abstract

OBJECTIVES:

We sought to describe the reproductive health of adolescent girls perinatally infected with HIV.

METHODS:

We estimated the incidence of first pregnancy, genital infections, and abnormal cervical cytology for 638 girls aged 13 years and older in the Pediatric AIDS Clinical Trials Group protocol 219C.

RESULTS:

Thirty-eight girls became pregnant, for a first pregnancy rate of 18.8/1000 person-years; 7 of these girls had additional pregnancies (95% confidence interval [CI]=13.3, 25.7). Thirty-two pregnancies resulted in live births. All girls received antiretroviral therapy during pregnancy. One infant was HIV infected, 29 were uninfected, and 2 had unknown infection status, for a rate of mother-to-child transmission of HIV in infants with known infection status of 3.3% (95% CI=0.1, 18.6). Condylomata and trichomoniasis were the most frequent genital infections. Forty-eight (47.5%) of 101 girls with Papanicolaou test examinations had abnormal cervical cytology, including atypical cells of undetermined significance (n=18), low-grade squamous intraepithelial lesions (SIL; n=27), and high-grade SIL (n=3). Many abnormalities persisted despite intervention.

CONCLUSIONS:

Pregnancy rates were lower and cervical abnormalities were higher than among non-HIV-infected adolescents. These findings underscore the importance of Papanicolaou tests and promotion of safer sexual practices in this population.

PMID:
17463385
PMCID:
PMC1874205
DOI:
10.2105/AJPH.2005.071910
[Indexed for MEDLINE]
Free PMC Article

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