Format

Send to

Choose Destination
Chem Biol. 2007 Apr;14(4):419-30.

LMP2-specific inhibitors: chemical genetic tools for proteasome biology.

Author information

1
Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536, USA.

Abstract

The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. However, its other pathophysiological functions are still not very well understood. This can be attributed mainly to a lack of appropriate molecular probes that can selectively modulate the immunoproteasome catalytic subunits. Herein, we report the development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome. We show that these compounds irreversibly modify the LMP2 subunit with high specificity. Importantly, LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of malignant tumors that highly express LMP2.

PMID:
17462577
PMCID:
PMC5541682
DOI:
10.1016/j.chembiol.2007.03.008
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center