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Ann Epidemiol. 2007 May;17(5):394-9.

Hypothesis: oxidative stress score as a combined measure of pro-oxidant and antioxidant exposures.

Author information

1
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA. mgoodm2@sph.emory.edu

Abstract

PURPOSE:

To explore the hypothesis that a combination of several risk factors acting through the same pathway may produce an overall large increase in risk even in the presence of weak associations with each individual factor.

METHODS:

Using oxidative stress pathway as an example, we propose an oxidative stress score (OSS), where high and low pro-oxidant exposures expressed as continuous variables are assigned values of 0 and 1, while high and low antioxidant exposures are assigned values of 1 and 0, respectively. Dichotomous variables for pro-oxidant and antioxidant exposures are scored in a similar fashion. All individual scores are then summed to calculate the overall OSS, where higher and lower values indicate a shift toward antioxidant and pro-oxidant exposures, respectively.

RESULTS:

We illustrate this approach by using data from two previously-conducted case-control studies: a colonoscopy-based colorectal adenoma study, and a population-based prostate cancer study. In this pilot illustration we found a substantial decrease in risk associated with a high OSS for both prostate cancer and colorectal adenoma. By contrast, analyses for individual OSS components demonstrated no discernible pattern.

CONCLUSIONS:

Our exploratory analyses serve as a demonstration of a method and warrant further confirmation on a larger scale.

PMID:
17462547
DOI:
10.1016/j.annepidem.2007.01.034
[Indexed for MEDLINE]

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