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Pediatr Dermatol. 2007 Mar-Apr;24(2):138-40.

The hair collar sign as a marker for neural tube defects.

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  • 1Southern Colorado Family Medicine Residency Program, St. Mary Corwin Medical Center, Pueblo, Colorado, USA.


The hair collar sign has been described as a marker of cranial dysraphism, including encephaloceles, meningoceles, and heterotropic brain tissue. This report describes a male born with a hair collar sign who subsequently was found to have a Klippel-Feil anomaly, diastematomyelia, multiple segmental spine and rib anomalies, and a translocation between chromosomes 1 and 4; t(1;4) (q44;q10). While not previously documented, spine abnormalities may be an associated abnormality with the hair collar sign. Physicians should consider radiographic evaluation of the spine in all newborns with a hair collar sign, as well as genetic screening.

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