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World J Gastroenterol. 2007 Mar 14;13(10):1585-94.

Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study.

Author information

1
Centre for Clinical and Population Sciences, Queen's University, Mulhouse Building, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland. l.anderson@qub.ac.uk

Abstract

AIM:

To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.

METHODS:

This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients, 227 oesophageal adenocarcinoma patients and 260 controls. All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.

RESULTS:

Gastro-oesophageal reflux was associated with Barrett's [OR 12.0 (95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48 (95% CI 2.25-5.41)]. Oesophageal adenocarcinoma patients were more likely than controls to be ex- or current smokers [OR 1.72 (95% CI 1.06-2.81) and OR 4.84 (95% CI 2.72-8.61) respectively] and to have a high body mass index [OR 2.69 (95% CI 1.62-4.46)]. No significant associations were observed between these risk factors and Barrett's oesophagus. Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50 (95% CI 0.30-0.86)].

CONCLUSION:

A high body mass index, a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma.

PMID:
17461453
PMCID:
PMC4146903
[Indexed for MEDLINE]
Free PMC Article

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