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Retina. 2007 Mar;27(3):269-75.

Role of genetic factors and inflammation in age-related macular degeneration.

Author information

1
Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, USA. dariusm@stanford.edu

Abstract

Complement factor H (CFH) has been implicated in the predisposition to advanced forms of age-related macular degeneration (AMD). The purpose of this review is to highlight recent discoveries implicating single nucleotide polymorphisms on 1q32, 6p21, and 10q26 in the risk for development of AMD. In addition, the central role of CFH in the complement cascade and its role in the inflammatory hypothesis for AMD are reviewed.

PMID:
17460581
DOI:
10.1097/IAE.0b013e31802e3e9b
[Indexed for MEDLINE]

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