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Eur Heart J. 2007 Aug;28(16):1962-7. Epub 2007 Apr 25.

Risk of dementia in stroke-free patients diagnosed with atrial fibrillation: data from a community-based cohort.

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Division of Cardiovascular Disease and Internal Medicine, Mayo Clinic, 200 First Street, SW., Rochester, MN 55905, USA.



To estimate the incidence of dementia after the first atrial fibrillation (AF), and its impact on survival in a community-based cohort.


Olmsted County, Minnesota adult residents diagnosed with first AF during 1986-2000 were identified, and followed until 2004. The primary outcome was new detection of dementia. Interim stroke was censored in the analyses. Of 2837 subjects (71 +/- 15 years old) diagnosed with first AF and without any evidence of cognitive dysfunction or stroke at the time of AF onset, 299 were diagnosed with dementia during a median follow-up of 4.6 years [interquartile (IQR) range 1.5-7.9 years], and 1638 died. The Kaplan-Meier cumulative rate of dementia was 2.7% at 1 year and 10.5% at 5 years. After adjustment for age and sex, dementia was strongly related to advancing age [hazard ratio (HR)/10 years, 2.8; 95% confidence interval (CI), 2.5-3.2], but did not vary with sex (P = 0.52). The occurrence of post-AF dementia was associated with significantly increased mortality risk (HR 2.9; 95% CI 2.5-3.3), even after adjustment for multiple comorbidities, and did not vary with age (P = 0.75) or sex (P = 0.33).


Dementia appeared common following the diagnosis of first AF, and was associated with premature death.

[Indexed for MEDLINE]

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