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Leg Med (Tokyo). 2007 Sep;9(5):251-7. Epub 2007 Apr 24.

The changes in AgNOR parameters of dorsal raphe nucleus neurons are related to suicide.

Author information

1
Institute of Forensic Medicine, Medical University of Gdańsk, Debowa 23, 80-204 Gdańsk, Poland. gost@amg.gda.pl

Erratum in

  • Leg Med (Tokyo). 2008 Jan;10(1):50.

Abstract

Depression has been established as the main cause of suicide and the research has concentrated on disturbed central serotonergic system in both disorders. The dorsal raphe nucleus (DRN) of brain stem is the main source of serotonergic innervation of limbic structures fundamental in the regulation of emotionally influenced behavior. The study was carried out on paraffin-embedded brains from 10 depressive patients, among them 5 suicides and 5 non-suicides and 13 matched mentally healthy controls. The karyometric parameters of DRN neurons were evaluated by AgNOR (Argyrophilic Nucleolar Organizer) silver staining method. The significant effect of suicide on nuclear area and AgNOR-ratio found in the cumulative analysis of all DRN subnuclei could be relevant for forensic diagnostic. The results suggest DRN neurons hypoactivity specific for suicide. Whether observed phenomenon is a "common trait" existing also in other diagnostic groups of mental disorders remains an open question.

PMID:
17459759
DOI:
10.1016/j.legalmed.2007.02.001
[Indexed for MEDLINE]

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