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Bioorg Med Chem Lett. 2007 Jun 15;17(12):3262-5. Epub 2007 Apr 10.

Discovery of new C3aR ligands. Part 2: amino-piperidine derivatives.

Author information

1
UCB Global Chemistry, Chemin du Foriest, R4, 1420 Braine l'Alleud, Belgium. frederic.denonne@ucb-group.com

Abstract

The synthesis and structure-activity relationships against the C3a receptor of a series of substituted aminopiperidine derivatives are reported. DMPK properties and functional activities of selected compounds are described. The compounds obtained are the first non-arginine ligands of C3aR.

PMID:
17459702
DOI:
10.1016/j.bmcl.2007.04.023
[Indexed for MEDLINE]

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