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Dermatol Online J. 2006 Dec 10;12(7):15.

Three cases of toxic skin eruptions associated with methotrexate and a compilation of methotrexate-induced skin eruptions.

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Dept of Dermatology, St Lukes Roosevelt Hospital Center, New York, NY, USA.


Methotrexate is an antimetabolite used as a treatment for a variety of neoplastic and inflammatory diseases. It has a variety of cutaneous side effects, in particular when administered in high doses. This is a report of cutaneous eruptions in three patients treated with methotrexate and a review of eruptions linked to methotrexate.

[Indexed for MEDLINE]

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