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Breast Cancer Res Treat. 2007 Dec;106(3):383-8. Epub 2007 Apr 26.

CYP1B1 and predisposition to breast cancer in Poland.

Author information

1
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.

Abstract

BACKGROUND:

The CYP1B1 gene is a polymorphic member of the P450 gene family and is considered to be a candidate gene for cancers of various types.

OBJECTIVE:

We inquired whether four SNPs in the CYP1B1 gene, alone or in combination, might be associated with breast cancer risk in Poland.

METHODS:

We genotyped 2017 cases of breast cancer and 876 controls, for four SNPs in the CYP1B1 gene. Genotype and haplotype frequencies were compared in cases and controls.

RESULTS:

In combinations of the R48G, A119S and L432V SNPs, four of the eight CYP1B1 haplotypes were more common in controls than in cases and each of these appeared to have a significant protective effect. A large reduction in risk was observed for women who were homozygous for one of these four haplotypes (OR = 0.2; 95%; CI = 0.05-0.5; P = 0.001) compared to women who were homozygous for the most common haplotype. In contrast, women who were homozygous for the GTC haplotype were at increased risk (OR = 1.5; 95%; CI = 1.0-2.1; P = 0.03) compared to women with the most common haplotype.

CONCLUSIONS:

The CYP1B1 gene appears to influence breast cancer susceptibility in Poland.

PMID:
17458695
DOI:
10.1007/s10549-007-9500-4
[Indexed for MEDLINE]

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