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Cancer Metastasis Rev. 2007 Jun;26(2):333-9.

Hypoxia, gene expression, and metastasis.

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1
Department of Radiation Oncology, Division of Cancer and Radiation Biology, Stanford University School of Medicine, Stanford, CA 94305-5152, USA.

Abstract

Hypoxia poses many problems to the treatment of cancer. Hypoxic tumors are more resistant to chemotherapy and radiation. In addition, hypoxia induces a number of genes responsible for increased invasion, aggressiveness, and metastasis of tumors. The augmented metastatic potential due to hypoxia-mediated gene expression is discussed in this section. Particular attention is given to recent studies of specific genes involved in the key steps of metastasis, including extracellular matrix interactions, migration, and proliferation.

PMID:
17458506
DOI:
10.1007/s10555-007-9063-1
[Indexed for MEDLINE]
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