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Nicotine Tob Res. 2007 Apr;9(4):443-6.

Depression during tobacco abstinence.

Author information

1
Department of Psychiatry, University of Vermont, Burlington, VT 05401-1419, USA. john.hughes@uvm.edu

Abstract

Many clinicians and scientists believe smoking cessation increases the risk of major depressive disorder (MDD), especially among those with a past history of the disorder. This literature review located seven empirical tests of this belief. All seven had significant methodological limitations. The incidence of MDD over 7-64 weeks postcessation was 0%-14% among all smokers who tried to stop, 3%-24% among smokers with a past history of MDD who tried to stop, and 1%-31% among smokers who became abstinent. Smokers with a past history of MDD were more likely to have postcessation MDD. Although some within-study comparisons suggest abstinence increased the incidence of MDD, a definitive conclusion cannot be made. Whether treatment with antidepressants prevented postcessation MDD also was unclear. This review makes methodological recommendations for more definitive studies.

PMID:
17454698
DOI:
10.1080/14622200701243185
[Indexed for MEDLINE]

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