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Crit Rev Microbiol. 2007;33(1):1-13.

Regulation of sugar catabolism in Lactococcus lactis.

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  • 1Department of Microbial Biochemistry, Institute of Biochemistry and Biophysics PAS, Pawinskiego, Warszawa, Poland.


The increasing number of genomic and post-genomic studies on Gram-positive organisms and especially on lactic acid bacteria brings a lot of information on sugar catabolism in these bacteria. Like for many other bacteria, glucose is the most preferred source of carbon and energy for Lactococcus lactis. Other carbon sources can induce their own utilization in the absence of well-metabolized sugar. These processes engage numbers of genes and undergo complex mechanisms of regulation. In this review, we discuss various biochemical and genetic control mechanisms involved in sugar catabolism, like regulation by repressors, activators, antiterminators or carbon catabolite repression control.

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