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Apoptosis. 2007 May;12(5):869-76.

Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program?

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1
Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.

Abstract

Mitochondria play a pivotal role in the process of apoptosis. Alterations in mitochondrial structure and function during apoptosis are regulated by proteins of the BCL-2 family, however their exact mechanism of action is largely unknown. Mitochondrial carriers and pores play an essential role in maintaining the normal function of mitochondria, and BCL-2 family members were shown to interact with several mitochondrial carriers/pores and to affect their function. This review focuses on the involvement of several of these mitochondrial carriers/pores in the regulation of the mitochondrial death pathway.

PMID:
17453157
DOI:
10.1007/s10495-007-0748-2
[Indexed for MEDLINE]
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