Format

Send to

Choose Destination
J Med Chem. 2007 May 17;50(10):2289-92. Epub 2007 Apr 24.

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.

Abstract

6-phenylpurines were identified as novel, ATP-competitive inhibitors of protein kinase B (PKB/Akt) from a fragment-based screen and were rapidly progressed to potent compounds using iterative protein-ligand crystallography with a PKA-PKB chimeric protein. An elaborated lead compound showed cell growth inhibition and effects on cellular signaling pathways characteristic of PKB inhibition.

PMID:
17451235
DOI:
10.1021/jm0700924
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center