Format

Send to

Choose Destination
J Med Chem. 2007 May 17;50(10):2293-6. Epub 2007 Apr 24.

Identification of inhibitors of protein kinase B using fragment-based lead discovery.

Abstract

Using fragment-based screening techniques, 5-methyl-4-phenyl-1H-pyrazole (IC50 80 microM) was identified as a novel, low molecular weight inhibitor of protein kinase B (PKB). Herein we describe the rapid elaboration of highly potent and ligand efficient analogues using a fragment growing approach. Iterative structure-based design was supported by protein-ligand structure determinations using a PKA-PKB "chimera" and a final protein-ligand structure of a lead compound in PKBbeta itself.

PMID:
17451234
DOI:
10.1021/jm070091b
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center