Topiramate attenuates a transient learning deficit after lesions inducing intracerebral hemorrhage

William F McDaniel; Alexandra Sondra Sawitsky; Kara E Vick

doi:10.2466/pr0.100.1.164-166

Topiramate attenuates a transient learning deficit after lesions inducing intracerebral hemorrhage

Psychol Rep. 2007 Feb;100(1):164-6. doi: 10.2466/pr0.100.1.164-166.

Authors

William F McDaniel¹, Alexandra Sondra Sawitsky, Kara E Vick

Affiliation

¹ Department of Psychology, Georgia College & State University, Milledgeville, GA 31061-0490, USA. bill.mcdaniel@gcsu.edu

PMID: 17451019
DOI: 10.2466/pr0.100.1.164-166

Abstract

28 male Long-Evans rats prepared with lesions of the middle cerebral artery displayed deficits in spatial navigational learning in a simple version of the Morris Water Maze task not seen in animals prepared with the same injury but administered 4 treatments with topiramate after surgery.

MeSH terms

Animals
Cerebral Hemorrhage / complications*
Disease Models, Animal
Fructose / analogs & derivatives*
Fructose / pharmacology
Fructose / therapeutic use
Learning Disabilities / drug therapy*
Learning Disabilities / etiology*
Male
Maze Learning / drug effects*
Neuroprotective Agents / pharmacology*
Neuroprotective Agents / therapeutic use*
Rats
Rats, Long-Evans
Topiramate

Substances

Neuroprotective Agents
Topiramate
Fructose