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Nat Rev Mol Cell Biol. 2007 May;8(5):345-54.

Stem-cell niches: nursery rhymes across kingdoms.

Author information

1
Molecular Genetics Group, Department of Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands. b.scheres@bio.uu.nl.

Abstract

Despite the large evolutionary distance between the plant and animal kingdoms, stem cells in both reside in specialized cellular contexts called stem-cell niches. Although stem-cell-specification factors have been recruited from plant-specific gene families, maintenance factors that repress stem-cell differentiation are conserved between plants and animals. Recent evidence indicates that stem cells in multicellular organisms can be specified by kingdom-specific patterning mechanisms that connect to a related core of epigenetic stem-cell factors.

PMID:
17450175
DOI:
10.1038/nrm2164
[Indexed for MEDLINE]

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